This was a collaborative project with researchers at the U.S. EPA that compared the sensitivity of different dipentyl phthalate responses in the rat fetal testis. We also used gene expression-based dose-response testing to identify sensitive changes that contribute to phthalate toxicity mechanisms. This information will be useful for risk assessment of phthalates.

Gupta MV, Conley JM, Lambright C, Chin LF, Hall SJ, Gray LE, Spade DJ. Dose-response assessment of dipentyl phthalate effects on testosterone production and morphogenesis of late-gestation fetal rat testis. Environment International; in press, May 22, 2025