Pathology and Laboratory Medicine

Publications

Breadcrumb

Publications

2026

2026 Publications

Cellular Senescence: A Novel Mechanism of Therapeutic Resistance in Prostate Cancer

Lin C, Hadfield MJ, Rathore A, Pinho-Schwermann M, Zhang S, Lu S, Hollander PD, Mani SA, Seyhan AA, Santopietro A, Mega A, Cheng L, El-Deiry WS, Carneiro BA. Cellular senescence: A novel mechanism of therapeutic resistance in prostate cancer. Cancer Treat Rev. 2026 Jan;142:103061. doi: 10.1016/j.ctrv.2025.103061. Epub 2025 Nov 28. PMID: 41330005.

A Patient with Newly Diagnosed Breast Cancer Found to Have Mosaic TP53 Likely Pathogenic Variant

Mistry HD, Adams MR, Taneja C, Massingham LJ, Dibble EH, Leonard KL, Hart J, Lagos GG, Fenton MA. CA Cancer J Clin. 2026 Jan-Feb;76(1):e70034. doi: 10.3322/caac.70034. Epub 2025 Sep 24. PMID: 40991533; PMCID: PMC12788344.

Histomorphology and Utility of CK17, p53 Dual Stain with CK 13 in the Diagnosis of Differentiated Vulvar Intraepithelial Neoplasia

Altarawneh BK, Quddus MR, Singh K, Sung CJ, Marketkar S. Ann Diagn Pathol. 2026 Feb;80:152561. doi: 10.1016/j.anndiagpath.2025.152561. Epub 2025 Sep 12. PMID: 40966818.

Collective Transitions from Orbiting to Matrix Invasion in Three-Dimensional Multicellular Spheroids

Kim J, Jeong H, Falcó C, Hruska AM, Martinson WD, Marzoratti A, Araiza M, Yang H, Fonseca VC, Adam SA, Franck C, Carrillo JA, Guo M, Wong IY.  Nat Phys. 2026 Feb;22(2):275-286. doi: 10.1038/s41567-025-03150-x. Epub 2026 Jan 26. PMID: 41728630; PMCID: PMC12919658.

Population Genetics of Plasmodium Vivax with Transmission Decline and Rebound in Two Endemic Areas of Papua New Guinea

Fola AA, Mehra S, Razook Z, Lautu-Gumal D, Nate E, Lee S, Kattenberg JH, Koepfli C, Kazura J, Ome-Kaius M, Laman M, Robinson LJ, Mueller I, Barry AE.  Front Genet. 2026 Feb 3;16:1621920. doi: 10.3389/fgene.2025.1621920. Erratum in: Front Genet. 2026 Feb 16;17:1805349. doi: 10.3389/fgene.2026.1805349. PMID: 41777528; PMCID: PMC12951784.

Malaria Control and the Unexpected Spread of Diagnostic-Resistant Plasmodium Falciparum in Peru

Gyuricza IG, Fola AA, Simkin A, Thwai KL, Juliano JJ, Bailey JA, Johri P, Henry CM, Cabrera-Sosa L, Porras-Laymito G, Cheng Q, Watson OJ, Gamboa D, Valdivia HO, Parr JB.  bioRxiv [Preprint]. 2026 Feb 26:2026.02.25.707493. doi: 10.64898/2026.02.25.707493. PMID: 42124593; PMCID: PMC13160032.

Structural Basis for the Recruitment and Selective Phosphorylation of Akt by mTORC2

Taylor MS, Chen M, Hancock M, Wranik M, Miller BD, O'Meara TR, Palanski BA, Ficarro SB, Groendyke BJ, Xiang Y, Kondo KT, Linde-Garelli KY, Lee MJ, Mondal D, Freund D, Congreve S, Matas K, Hennink M, Xibinaku K, Valenstein ML, van Eeuwen T, Marto JA, Sali A, Shi Y, Gray NS, Sabatini DM, Chu N, Rogala KB, Cole PA.  Science. 2026 Mar 5;391(6789):eadv7111. doi: 10.1126/science.adv7111. Epub 2026 Mar 5. PMID: 41308123; PMCID: PMC12830033.

Functional Validation of the Plasmodium Falciparum K13 C580Y Mutation in Recently Collected Ethiopian Isolates

Mukherjee A, Assefa AB, Turlo CV, Needham LC, Shoue D, Qahash T, Belachew M, Tadesse D, Kassie E, Berihun M, Brhane BG, Parr JB, Ferdig MT; members of the MAREE Consortium; Adane S, Tesfaye A, Zuromski J, Fola AA, Tasew G, Tollera G, Juliano JJ, Bailey JA.  bioRxiv [Preprint]. 2026 Mar 17:2026.03.17.712112. doi: 10.64898/2026.03.17.712112. Update in: Antimicrob Agents Chemother. 2026 Sep 9:e0049526. doi: 10.1128/aac.00495-26. PMID: 41889897; PMCID: PMC13015332.

Recurrent Parasitemias with Artemisinin Partial Resistance Mutations During the 2024 Ethiopia Malaria Resurgence: A Case Series

Geleta D, Brhane BG, Abera A, Belachew M, Sime H, Gebreegziaxher A, Getu M, Ali A, Tesfaye N, Habtetsion M, Kokobe B, Kebede M, Worku Z, Tasew G, Tadesse G, Tollera G, Fola AA, Bailey JA, Juliano JJ, Parr JB, Abte M, Assefa A.  Res Sq [Preprint]. 2026 Mar 18:rs.3.rs-9094035. doi: 10.21203/rs.3.rs-9094035/v1. Update in: Malar J. 2026 Jul 31;25(1):315. doi: 10.1186/s12936-026-06078-6. PMID: 41890835; PMCID: PMC13015592.

Exploiting Metabolic Vulnerabilities to Improve Cancer Therapeutics

Ibrahim IH, Lin CH, Zhou M, Yang JY, Sobol RW, Tan M.  Trends Endocrinol Metab. 2026 Apr;37(4):339-355. doi: 10.1016/j.tem.2025.08.002. Epub 2025 Aug 28. PMID: 40883193.

Endometrial Gastric (Gastrointestinal)-Type Mucinous Adenocarcinoma: Diagnostic Criteria, Differential Diagnosis, and Molecular Insights

Nam GH, Tan HM, Quddus MR, Dong J, Singh K, Sung CJ, Cheng L.  Hum Pathol. 2026 Apr;170:106031. doi: 10.1016/j.humpath.2025.106031. Epub 2025 Dec 30. PMID: 41475433.

Cancer-Associated Fibroblasts Regulate DNA Repair in Pancreatic Cancer Through NDRG1-Mediated R-Loop Processing

Kozlova N, Cruz KA, Ruzette AA, Doh HM, Willis NA, Hong SM, Gonzalez RS, Vyas M, Selfors LM, Dreyer S, Upstill-Goddard R, Faia KL, Wenglowsky S, Close J, Beutel A, Jutric Z, Oliphant MUJ, Poluben L, Thapa B, Taylor MS, Mustonen V, Mangalath P, Halbrook CJ, Grossman JE, Hwang RF, Clohessy JG, Ruskamo S, Kursula P, Petrova B, Kanarek N, Cole PA, Chang DK, Evans CL, Nørrelykke SF, Scully R, Muranen T.  Nat Cell Biol. 2026 May;28(5):986-999. doi: 10.1038/s41556-026-01938-4. Epub 2026 Apr 27. PMID: 42045570; PMCID: PMC13179137.

Leiomyosarcoma With Dedifferentiation Mimicking a Benign Neoplasm

Hoang M, Mirza FN, Wang AR, DiMarco C, Hart J, Robinson-Bostom L, Libby TJ.  Am J Dermatopathol. 2026 May 1;48(5):367-369. doi: 10.1097/DAD.0000000000003243. Epub 2026 Feb 19. PMID: 41711635.

Genomic and Clinicopathological Characteristics of Low Oncotype Recurrent Score Breast Cancers with Subsequent Metastasis

Liu L, Graff SL, Hacking S, Cheng L, Wang Y.  Histopathology. 2026 Jun;88(7):1451-1458. doi: 10.1111/his.70115. Epub 2026 Feb 10. PMID: 41664643.

2025

2026 Publications

O Blood Usage Trends in the Pediatric Population 2015-2019: A Multi-Institutional Analysis

Annen K, Andani S, Bosma G, Abbott D, Arinsburg S, Nguyen F, Ibeh N, Nicol K, Hernandez P, Jackups R, Delaney M, Bahar B, Mo Y, Alexander B, Noland DK, Wong TE, Andrews J.  Transfusion. 2025 Apr;65(4):676-683. doi: 10.1111/trf.18225. Epub 2025 Mar 28. PMID: 40151072; PMCID: PMC12057999.

Rapid DNA Cleavage by the LINE-1 Endonuclease Proximal to DNA Ends and at Mismatches

Miller BD, Smail BA, Van Eeuwen T, Kodama H, Kondo K, Jiang H, O'Brien A, Dai N, Trachman RJ 3rd, Guan S, Karlow JA, Cheng WC, Sedivy JM, Jogl G, Rout MP, LaCava J, Burns KH, Taylor MS.  J Biol Chem. 2026 Jan;302(1):110994. doi: 10.1016/j.jbc.2025.110994. Epub 2025 Nov 29. PMID: 41325800; PMCID: PMC12809410.

Primary Adenocarcinoma of the Urinary Tract and Its Precursors: Diagnostic Criteria and Classification

Santa F, Akgul M, Tannous E, Pacheco RR, Lightle AR, Mohanty SK, Cheng L.  Hum Pathol. 2025 Jan;155:105734. doi: 10.1016/j.humpath.2025.105734. Epub 2025 Feb 21. PMID: 39988060.

Continued Positive Job Search Experience for New Pathologists Seeking First Employment During the COVID-19 Pandemic (2020-2022)

Karp JK, Lofgreen A, Johnson K, George MR, Barak S, Bryant BH, Berg MP, Childs JM, Knollman-Ritschel BEC, Prieto VG, White KL, McCloskey CB. Arch Pathol Lab Med. 2025 Jan 1;149(1):14-19. doi: 10.5858/arpa.2023-0408-CP. PMID: 38528091.

Identifying Mesonephric-Like Adenocarcinoma of the Endometrium by Combining SOX17 and PAX8 Immunohistochemistry

Tahir M, Xing D, Ding Q, Wang Y, Singh K, Suarez AA, Parwani A, Li Z.  Histopathology. 2025 Jan;86(2):268-277. doi: 10.1111/his.15312. Epub 2024 Sep 4. PMID: 39233315; PMCID: PMC11649513.

Amino Acids and KLHL22 Do Not Activate mTORC1 via DEPDC5 Degradation

Valenstein ML, Lalgudi PV, Kedir JF, Condon KJ, Platzek A, Freund DG, Taylor MS, Xu Y, Chivukula RR, Sabatini DM.  Nature. 2025 Jan;637(8045):E11-E14. doi: 10.1038/s41586-024-07974-0. Epub 2025 Jan 8. PMID: 39780017.

SS18-SSX Expression and Clinicopathologic Profiles in a Contemporary Cohort of Primary Paratesticular Synovial Sarcoma: A Series of Fourteen Patients

Lobo A, Mishra SK, Acosta AM, Kaushal S, Akgul M, Williamson SR, Sangoi AR, Aron M, Kandukuri SR, Shinde S, Sharma S, Jain E, Dhillon J, Deshwal A, Peddinti K, Jaiswal S, Das S, Kapoor R, Biswas G, Pradhan MR, Osunkoya AO, Pradhan D, Chakrabarti I, Jha S, Parwani AV, Shah RB, Amin MB, Cheng L, Mohanty SK.  Am J Surg Pathol. 2025 Jan 1;49(1):11-19. doi: 10.1097/PAS.0000000000002323. Epub 2024 Oct 25. PMID: 39449577.

SRC Enhanced Cisplatin Resistance in Bladder Cancer by Reprogramming Glycolysis and Pentose Phosphate Pathway

Gong Y, Gao D, Shi Y, Fan G, Yu X, Yang E, Cheng H, Tian J, Ding H, Liu S, Fu S, Tao Y, Shui Y, Cheng L, Li L, Wang Z.  Commun Biol. 2025 Jan 10;8(1):36. doi: 10.1038/s42003-024-07284-1. PMID: 39794543; PMCID: PMC11724026.

Trail Agonists Rescue Mice from Radiation-Induced Lung, Skin, or Esophageal Injury

Strandberg J, Louie A, Lee S, Hahn M, Srinivasan P, George A, De La Cruz A, Zhang L, Hernandez Borrero L, Huntington KE, De La Cruz P, Seyhan AA, Koffer PP, Wazer DE, DiPetrillo TA, Graff SL, Azzoli CG, Rounds SI, Klein-Szanto AJ, Tavora F, Yakirevich E, Abbas AE, Zhou L, El-Deiry WS.  J Clin Invest. 2025 Jan 14;135(5):e173649. doi: 10.1172/JCI173649. PMID: 39808500; PMCID: PMC11870730.

Small Cell Lung Cancer and Prostate Cancer Cells with Varying Neuroendocrine Differentiation Markers Show Sensitivity to Imipridone ONC201/TIC10

Ding E, Pinho-Schwermann M, Zhang S, Purcell C, El-Deiry WS.  Am J Transl Res. 2025 Jan 15;17(1):104-115. doi: 10.62347/IBUS3598. PMID: 39959215; PMCID: PMC11826210.

The Atlas of Protein-Protein Interactions in Cancer (APPIC)-a Webtool to Visualize and Analyze Cancer Subtypes

Ahn B, Chou C, Chou C, Chen J, Zug A, Baykara Y, Claus J, Hacking SM, Uzun A, Gamsiz Uzun ED.  NAR Cancer. 2025 Jan 15;7(1):zcae047. doi: 10.1093/narcan/zcae047. PMID: 39822275; PMCID: PMC11734624.

Trail Receptor Agonist TLY012 in Combination with PD-1 Inhibition Promotes Tumor Regression in an Immune-Competent Mouse Model of Pancreatic Ductal Adenocarcinoma

Louie AD, Huntington KE, Lee Y, Mompoint J, Wu LJ, Lee S, Miner TJ, El-Deiry WS.  Am J Cancer Res. 2025 Jan 15;15(1):286-298. doi: 10.62347/ROAT5658. PMID: 39949937; PMCID: PMC11815385.

Molecular and Immune Landscape of Tumours in Geriatric Patients with Non-Small Cell Lung Cancer, Melanoma and Renal Cell Carcinoma

Choucair K, Elliott A, Oberley MJ, Walker P, Salama AK, Saeed A, Mamdani H, Uprety D, El-Deiry WS, Beltran H, Liu SV, Kim C, Naqash AR, Lou E, Chen L, Saeed A. BMJ Oncol. 2025 Jan 16;4(1):e000551. doi: 10.1136/bmjonc-2024-000551. PMID: 39885940; PMCID: PMC11751915.

Multi-Assay Assessment of Cytotoxicity Reveals Multiple Mechanisms of Action in 3D Microtissues

Zein-Sabatto A, St Angelo K, Madnick SJ, Hoffman-Kim D, Morgan JR, Lee J.  Sci Rep. 2025 Jan 24;15(1):3090. doi: 10.1038/s41598-025-86792-4. PMID: 39856149; PMCID: PMC11759695.

Heterogeneity in Cancer

MacDonald WJ, Purcell C, Pinho-Schwermann M, Stubbs NM, Srinivasan PR, El-Deiry WS. Cancers (Basel). 2025 Jan 28;17(3):441. doi: 10.3390/cancers17030441. PMID: 39941808; PMCID: PMC11816170.

Selection of Force Sensors for In Situ Measurement of Neotissue Microenvironments

Rodriguez Navas M, Darling EM. Tissue Eng Part A. 2025 Feb;31(3-4):164-173. doi: 10.1089/ten.tea.2024.0192. Epub 2024 Oct 25. PMID: 39453885; PMCID: PMC11971539.

Locoregional Event or Dyssynchronous Distant Metastasis: Clinicopathological and Molecular Analysis of Contralateral Axillary Lymph Node Metastasis in Breast Cancer Patients

Wang Y, Liu L, Graff SL, Cheng L. Histopathology. 2025 Feb;86(3):472-477. doi: 10.1111/his.15345. Epub 2024 Oct 22. PMID: 39435750.

Is Axillary Lymph Node Dissection Needed? Clinicopathological Correlation in a Series of 224 Neoadjuvant Chemotherapy-Treated Node-Positive Breast Cancers

Hacking SM, Wu D, Taneja C, Graves T, Cheng L, Wang Y.  Clin Breast Cancer. 2025 Feb;25(2):172-179. doi: 10.1016/j.clbc.2024.11.007. Epub 2024 Nov 10. PMID: 39613673.

Digital and Computational Transition in the Pathology Lab: When Did It Start?

Montironi R, Lopez-Beltran A, Cimadamore A, Cheng L.  Pathologica. 2025 Feb;117(1):60-62. doi: 10.32074/1591-951X-N824. PMID: 40205934; PMCID: PMC11983077.

Lab-Grown, 3D Extracellular Matrix Particles Improve Cardiac Function and Morphology in Myocardial Ischemia

Broadwin M, St Angelo K, Petersen M, Teixeira RB, Harris DD, Stone CR, Xu C, Kanuparthy M, Sellke FW, Morgan J, Abid MR. Am J Physiol Heart Circ Physiol. 2025 Feb 1;328(2):H221-H234. doi: 10.1152/ajpheart.00581.2024. Epub 2024 Dec 20. PMID: 39705507; PMCID: PMC12184076.

Navigating Management of Localized Prostate Cancer in the Geriatric Population

Malshy K, Golijanin B, Khaleel S, Danaher K, Widener J, Schmit S, Lagos G, Carneiro B, Amin A, Cheng L, Pareek G, Mega A, Golijanin D, Hyams E.  Crit Rev Oncol Hematol. 2025 Feb;206:104600. doi: 10.1016/j.critrevonc.2024.104600. Epub 2024 Dec 19. PMID: 39709068.

Placental Mesenchymal Dysplasia with Unique Chromosomal Abnormality and Unusual Histopathology: A Case Report and Literature Review

Al-Tarawneh BK, Kostadinov S, Tatevian N. Placental Mesenchymal Dysplasia with Unique Chromosomal Abnormality and Unusual Histopathology: A Case Report and Literature Review. Fetal Pediatr Pathol. 2025 Jan-Feb;44(1):69-74. doi: 10.1080/15513815.2024.2431988. Epub 2024 Nov 29. PMID: 39611285.

Application of a New Highly Multiplexed Amplicon Sequencing Tool to Evaluate Plasmodium Falciparum Antimalarial Resistance and Relatedness in Individual and Pooled Samples from Dschang, Cameroon

Sadler JM, Simkin A, Tchuenkam VPK, Gerdes Gyuricza I, Fola AA, Wamae K, Assefa A, Niaré K, Thwai K, White SJ, Moss WJ, Dinglasan RR, Nsango SE, Tume CB, Parr JB, Ali IM, Bailey JA, Juliano JJ.  Front Parasitol. 2025 Feb 5;3:1509261. doi: 10.3389/fpara.2024.1509261. PMID: 39975479; PMCID: PMC11835963.

Targeted Detection of Endogenous LINE-1 Proteins and ORF2p Interactions

Nielsen MI, Wolters JC, Bringas OGR, Jiang H, Di Stefano LH, Oghbaie M, Hozeifi S, Nitert MJ, van Pijkeren A, Smit M, Ter Morsche L, Mourtzinos A, Deshpande V, Taylor MS, Chait BT, LaCava J.  Mob DNA. 2025 Feb 6;16(1):3. doi: 10.1186/s13100-024-00339-4. PMID: 39915890; PMCID: PMC11800616.

Biguanides Antithetically Regulate Tumor Properties by the Dose-Dependent Mitochondrial Reprogramming-Driven c-Src Pathway

Park JH, Jung KH, Jia D, Yang S, Attri KS, Ahn S, Murthy D, Samanta T, Dutta D, Ghidey M, Chatterjee S, Han SY, Pedroza DA, Tiwari A, Lee JV, Davis C, Li S, Putluri V, Creighton CJ, Putluri N, Dobrolecki LE, Lewis MT, Rosen JM, Onuchic JN, Goga A, Kaipparettu BA. Cell Rep Med. 2025 Feb 18;6(2):101941. doi: 10.1016/j.xcrm.2025.101941. Epub 2025 Feb 10. PMID: 39933530; PMCID: PMC11866546.

Artemisinin Partial Resistance Mutations in Zanzibar and Tanzania Suggest Regional Spread and African Origins, 2023

Connelly SV, Muller JG, Ali M, Ngasala BE, Hassan W, Mohamed B, Thwai KL, Sadler JM, Marglous J, Fola AA, Zacharia A, Shija SJ, Mohammed S, C Msolo D, Said H, Peter EE, Odas M, Rutha IJ, Nwange M, Naire K, Ruybal-Pesántez S, Verity R, Crudale R, Goel V, Choloi BB, Björkman A, Bailey JA, Lin JT, Juliano JJ.  J Infect Dis. 2026 Feb 18;233(2):e491-e495. doi: 10.1093/infdis/jiaf431. PMID: 40802860; PMCID: PMC13017645.

Accelerating the Future of Oncology Drug Development: The Role of Consortia in the Delivery of Precision Oncology Early Phase Clinical Trials

Liu J, Farrow M, Seymour L, Desai J, Loong HH, Ivy P, Koyoma T, Cook N, Blagden S, Garralda E, Massard C, Tolcher AW, Adashek JJ, Zhang L, Zhao S, Shen L, Kurzrock R, El-Deiry WS, Subbiah V, Joshua AM.  J Clin Oncol. 2025 Feb 20;43(6):735-747. doi: 10.1200/JCO-24-01534. Epub 2025 Jan 14. PMID: 39808749.

Enhanced Efficacy of Immune Checkpoint Inhibitors by Folate-Targeted Multifunctional Drug Through Synergistic Therapy Inducing Ferroptosis and Immunogenic Cell Death in Bladder Cancer

Shi Y, Fan G, Yang E, Zhang Y, Ding H, Tian J, Cheng L, Wang H, Hao T, Wang B, Wang Z.  Mater Today Bio. 2025 Feb 21;31:101584. doi: 10.1016/j.mtbio.2025.101584. PMID: 40104638; PMCID: PMC11919378.

Bisulfite-Free PCDHGB7 Methylation in Urine Enables Early Noninvasive Detection of Urothelial Carcinoma

Yang Z, Chen Q, Dong S, Xu P, Mao Z, Dong Y, Li W, Li W, Han Y, Dai L, Dong G, Zhang Y, Li Y, Cheng L, Ci W, Yu W, Xu C.  Bioeng Transl Med. 2025 Feb 26;10(4):e70004. doi: 10.1002/btm2.70004. PMID: 40708980; PMCID: PMC12284432.

Prognostic Significance of Programmed Cell Death-1, Programmed Cell Death-Ligand 1, Programmed Cell Death-Ligand 2, and Fibroblast Growth Factor Receptor 3 mRNA Expression in Bladder Cancer

Blanca A, Lopez-Beltran A, Gomez-Gomez E, Campos-Hernández P, Cimadamore A, Montironi R, Cheng L.  Pathobiology. 2025;92(4):202-215. doi: 10.1159/000544733. Epub 2025 Feb 26. PMID: 40010309.

Studies of Slc30a10 Deficiency in Mice Reveal That Intestinal Iron Transporters Dmt1 and Ferroportin Transport Manganese

Prajapati M, Zhang JZ, Chong GS, Chiu L, Mercadante CJ, Kowalski HL, Antipova O, Lai B, Ralle M, Jackson BP, Punshon T, Guo S, Aghajan M, Bartnikas TB. Cell Mol Gastroenterol Hepatol. 2025;19(7):101489. doi: 10.1016/j.jcmgh.2025.101489. Epub 2025 Feb 28. PMID: 40024532; PMCID: PMC12264432.

Modulation of Blood-Tumor Barrier Transcriptional Programs Improves Intratumoral Drug Delivery and Potentiates Chemotherapy in GBM

Jimenez-Macias JL, Vaughn-Beaucaire P, Bharati A, Xu Z, Forrest M, Hong J, Sun M, Schmidt A, Clark J, Hawkins W, Mercado N, Real J, Huntington K, Zdioruk M, Nowicki MO, Cho CF, Wu B, Li W, Logan T, Manz KE, Pennell KD, Fedeles BI, Bertone P, Punsoni M, Brodsky AS, Lawler SE.  Sci Adv. 2025 Feb 28;11(9):eadr1481. doi: 10.1126/sciadv.adr1481. Epub 2025 Feb 26. PMID: 40009687; PMCID: PMC11864199.

Unexpectedly High Variability in Determining Tumour Extent in Prostatic Biopsies: Implications for Active Surveillance

Bernhardt M, Weinhold L, Bremmer F, Chan E, Cheng L, Collins K, Downes M, Greenland N, Hommerding O, Iczkowski KA, Jufe L, Kreft T, van Leenders G, Oxley J, Perry-Keene J, Reis H, Schmid M, Tsuzuki T, Wobker S, Wiliamson SR, Kweldam C, Kristiansen G.  Histopathology. 2025 Mar;86(4):627-639. doi: 10.1111/his.15372. Epub 2024 Nov 28. PMID: 39610035; PMCID: PMC11791730.

Novel Computational Pipeline Enables Reliable Diagnosis of Inverted Urothelial Papilloma and Distinguishes It From Urothelial Carcinoma

Shao W, Cheng M, Lopez-Beltran A, Osunkoya AO, Zhang J, Cheng L, Huang K.  JCO Clin Cancer Inform. 2025 Mar;9:e2400059. doi: 10.1200/CCI.24.00059. Epub 2025 Mar 13. PMID: 40080780.

Cellular Senescence Predicts Breast Cancer Risk from Benign Breast Disease Biopsy Images

Heckenbach I, Peila R, Benz C, Weinmann S, Wang Y, Powell M, Scheibye-Knudsen M, Rohan T.  Breast Cancer Res. 2025 Mar 11;27(1):37. doi: 10.1186/s13058-025-01993-z. PMID: 40069863; PMCID: PMC11900263.

LINE-1 ORF1p Expression Occurs in Clear Cell Ovarian Carcinoma Precursors and is a Candidate Blood Biomarker

de Santiago PR, Sato S, Zhang SJ, Dougher MC, Devins KM, Bilecz AJ, Rayamajhi S, Mingo G, Rendulich HS, Feng Y, Wu C, Taylor MS, Zhuravlev Y, Jung E, Omran DK, Wang TL, Shih IM, Schwartz LE, Kim S, Morgan MA, Tanyi JL, Burns KH, Lengyel E, Parra-Herran C, Godwin AK, Walt DR, Drapkin R.  NPJ Precis Oncol. 2025 Mar 6;9(1):62. doi: 10.1038/s41698-025-00849-1. PMID: 40050409; PMCID: PMC11885553.

An in Vitro Model to Measure the Strength and Stiffness of the Extracellular Matrix Synthesized de Novo by Human Fibroblasts

Wu Y, Millender J, Padgett B, Marx M, Madnick S, Puterbaugh R, Angelo KS, Hopkins CM, Morgan JR. In Vitro Model. 2025 Mar 7;4(1):59-69. doi: 10.1007/s44164-025-00081-y. PMID: 40160211; PMCID: PMC11950444.

ASPH Is a Metastatic Factor and Therapeutic Target in Chondrosarcoma

Sun X, Hart J, Taliano R, Molino J, Schwab JH, Nota S, Nagaoka K, Zhang S, Olsen M, Carlson R, Wands J, Terek RM. Cancers (Basel). 2025 Mar 12;17(6):951. doi: 10.3390/cancers17060951. PMID: 40149287; PMCID: PMC11939963.

Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine: Bringing Next-Generation Precision Oncology to Patients

El-Deiry WS, Bresson C, Wunder F, Carneiro BA, Dizon DS, Warner JL, Graff SL, Azzoli CG, Wong ET, Cheng L, Mani SA, Safran HP, Williams C, Meissner T, Solomon B, Rubin E, Porgador A, Berchem G, Saintigny P, Onn A, Bar J, Berger R, Gantenbein M, Chen Z, Souza CP, Reis RMV, Sekacheva M, Cervantes A, Dahut WL, Annunziata CM, Gober K, Musallam KM, Al-Shamsi HO, Abu-Gheida I, Salazar R, Limaye S, Aref AT, Reddel RR, Homsi MUA, Rouf A, Dermime S, Suwaidi JA, Vlad C, Buiga R, Omari AA, Abdel-Razeq H, Oñate-Ocaña LF, Nielsen FC, Graham L, Rueter J, Joshua AM, Girda E, Libutti S, Riedlinger G, Salem ME, Farhangfar CJ, Mesa RA, Faltas BM, Elemento O, Pramesh CS, Sengar M, Aoyama S, Ikeda S, Berindan-Neagoe I, Gaddipati H, Kulkarni M, Auzias E, Gerogianni M, Wolikow N, Istolainen S, Schlafrig P, Frankel NZ, Ferraro AR, Palma J, Gimenez AP, Hernando-Calvo A, Felip E, Tsimberidou AM, Herbst RS, Tabernero J, Schilsky RL, Liu J, Lussier Y, Raynaud J, Batist G, Magidi S, Kurzrock R.  Oncotarget. 2025 Mar 12;16:140-162. doi: 10.18632/oncotarget.28703. PMID: 40073368; PMCID: PMC11907938.

Signaling Pathway Dysregulation in Breast Cancer

Ryspayeva D, Seyhan AA, MacDonald WJ, Purcell C, Roady TJ, Ghandali M, Verovkina N, El-Deiry WS, Taylor MS, Graff SL. Oncotarget. 2025 Mar 13;16:168-201. doi: 10.18632/oncotarget.28701. PMID: 40080721; PMCID: PMC11906143.

Identification of Substituted 4-Aminocinnolines as Broad-Spectrum Antiparasitic Agents

Spaulding A, Sharma A, Giardini MA, Hoffman B, Bernatchez JA, McCall LI, Calvet CM, Ackermann J, Souza JM, Thomas D, Millard CC, Devine WG, Singh B, Silva EM, Leed SE, Roncal NE, Penn EC, Erath J, Kumar G, Sepulveda Y, Garcia A, Rodriguez A, El-Sakkary N, Sciotti RJ, Campbell RF, Momper JD, McKerrow JH, Caffrey CR, Siqueira-Neto JL, Pollastri MP, Mensa-Wilmot K, Ferrins L.  ACS Infect Dis. 2025 Mar 14;11(3):584-599. doi: 10.1021/acsinfecdis.4c00666. Epub 2025 Feb 12. PMID: 39936822; PMCID: PMC11915375.

Reduced EZH1/2 Expression in Imipridone-Treated Cells Correlates with Synergy Following Combinations with EZH1/2 or HDAC Inhibitors in Diffuse Glioma and Other Tumors

Zhang Y, Huntington KE, Seyhan AA, Tapinos N, Lulla RR, Monje M, Wong ET, Chen CC, El-Deiry WS.  Am J Cancer Res. 2025 Mar 15;15(3):1307-1320. doi: 10.62347/DZAT5333. PMID: 40226473; PMCID: PMC11982711.

IGV-001 Cellular Immunotherapy for Newly Diagnosed Glioblastoma: Overcoming the Logistic Challenge

Wong ET, Cielo D, Svokos K, Doberstein C, Sampath P, Donahue JE, Punsoni M, Rodrigues N, Rothell F, Edwards R, Wang E, Riccelli T, Chuck C, Shaaya EA, Sastry R, Ali R, Shao B, Abdulrazeq H, Sun FW, Feler J, Santos Fontánez SE, Nieves NA, Dobertsein C, Dailey J, Yu C, Sarangi S, Elinzano H, Boxerman JL, Yu E, Safran H, Seyhan AA, El-Deiry WS, Keith S, Gokaslan ZL, Chen CC, Malik A. Front Oncol. 2025 Mar 18;15:1556450. doi: 10.3389/fonc.2025.1556450. PMID: 40171253; PMCID: PMC11959700.

Imipridones ONC201/ONC206 + RT/TMZ Triple (IRT) Therapy Reduces Intracranial Tumor Burden, Prolongs Survival in Orthotopic IDH-WT GBM Mouse Model, and Suppresses MGMT

Zhou L, Zhang L, Zhang J, Wu LJ, Zhang S, George A, Hahn M, Safran HP, Chen CC, Seyhan AA, Wong ET, El-Deiry WS.  Oncotarget. 2025 Mar 27;16:230-248. doi: 10.18632/oncotarget.28707. PMID: 40145650; PMCID: PMC11948724.

Comparison of Nanopore with Illumina Whole Genome Assemblies of the Epstein-Barr Virus in Burkitt Lymphoma

Kim IE Jr, Fola AA, Puig E, Maina TK, Hui ST, Ma H, Zuckerman K, Agwati EO, Leonetti A, Crudale R, Luftig MA, Moormann AM, Oduor C, Bailey JA. Sci Rep. 2025 Mar 31;15(1):10970. doi: 10.1038/s41598-025-94737-0. PMID: 40164811; PMCID: PMC11958722.

Clinicopathologic Characteristics of Ductal Carcinoma in Situ and Risk of Subsequent Invasive Breast Cancer: A Multicenter, Population-Based Cohort Study

Rohan TE, Wang Y, Couch F, Feigelson HS, Greenlee RT, Honda S, Stark A, Chitale D, Zhang C, Xue X, Ginsberg M, Loudig O.  Breast Cancer Res Treat. 2025 Apr;210(3):615-625. doi: 10.1007/s10549-024-07599-x. Epub 2025 Jan 20. PMID: 39832051; PMCID: PMC11953078.

Targeted Therapeutic Approaches for the Treatment of Cancer: The Future Is Bright

Hadfield MJ, Carneiro BA, Cheng L.  J Pers Med. 2025 Apr 2;15(4):141. doi: 10.3390/jpm15040141. PMID: 40278320; PMCID: PMC12028791.

Intratumoral Mycobiome Heterogeneity Influences the Tumor Microenvironment and Immunotherapy Outcomes in Renal Cell Carcinoma

Mou W, Deng Z, Zhu L, Jiang A, Lin A, Xu L, Deng G, Huang H, Guo Z, Zhu B, Wu S, Yang T, Wang L, Liu Z, Wei T, Zhang J, Cheng L, Huang H, Chen R, Shao Y, Cheng Q, Wang L, Yuan S, Luo P.  Sci Adv. 2025 Apr 11;11(15):eadu1727. doi: 10.1126/sciadv.adu1727. Epub 2025 Apr 9. PMID: 40203108; PMCID: PMC11980860.

Urothelial Carcinoma in Situ with “Early Papillary Formation” Vs “Lateral Spread/Shoulder Lesion” of Prior High-Grade Noninvasive Papillary Urothelial Carcinoma: A Survey of Pathologist and Urologist Interpretations

Sangoi AR, Shahabi A, Hirsch MS, Kao CS, Deebajah M, Barletta JA, Paner GP, Smith SC, Grignon DJ, Compérat E, Amin MB, Maclean F, Shah RB, Iczkowski KA, Delprado W, Cheng L, Pan CC, McKenney JK, Ro JY, Khani F, Montironi R, Robinson BD, Al-Ahmadie H, Epstein JI, Trpkov K, Tretiakova M, Shen SS, Alanee S, Weight CJ, Akgul M, Williamson SR.  Am J Clin Pathol. 2025 Apr 19;163(4):629-640. doi: 10.1093/ajcp/aqae167. PMID: 39720998.

Respectful Closure of a CEnR DNA Integrity Study: A Bridge to Sustained Interactions with Research Participants

Arrieta MI, Parker LL, Sutherland E, Sobol RW.  J Clin Transl Sci. 2025 Apr 28;9(1):e110. doi: 10.1017/cts.2025.82. PMID: 40529005; PMCID: PMC12171911.
 


 

Extra-Axial Small Cell Prostate Carcinoma Intracranial Metastasis: Illustrative Case

Porto C, Abdulrazeq H, Sastry R, Chang A, Riccelli T, Punsoni M, Sampath P.  J Neurosurg Case Lessons. 2025 Apr 28;9(17):CASE24705. doi: 10.3171/CASE24705. PMID: 40294525; PMCID: PMC12036363.

Genetic Metrics Decode Plasmodium Falciparum Diversity: Complexity of Infection, Parasite Connectivity, and Transmission Intensity in Mainland Tanzania’s Diverse Regions

Pereus D, Fola AA, Bakari C, Seth MD, DeFeo R, Lyimo BM, Mandara CI, Madebe RA, Mbata D, Popkin-Hall ZR, Moshi R, Mbwambo RB, Mbwambo D, Aaron S, Lusasi A, Lazaro S, Giesbrecht DJ, Kulohoma B, Juliano JJ, Bailey JA, Juma G, Mobegi VA, Ishengoma DS. Front Genet. 2026 Apr 29;17:1695073. doi: 10.3389/fgene.2026.1695073. PMID: 42137244; PMCID: PMC13168215.

National Genomic Profiling of Plasmodium Falciparum Antimalarial Resistance in Zambian Children Participating in the 2018 Malaria Indicator Survey

Fola AA, Ciubotariu II, Dorman J, Mwenda MC, Mambwe B, Mulube C, Kasaro R, Hawela MB, Hamainza B, Miller JM, Bailey JA, Moss WJ, Bridges DJ, Carpi G. Sci Rep. 2026 Apr 30;16(1):20113. doi: 10.1038/s41598-026-45996-y. PMID: 42062354; PMCID: PMC13324043.

Myoid Hamartoma of the Breast With HMGA2 Rearrangement and Associated In-Situ and Invasive Carcinoma: Case Report and Review of Literature

Sta Ines FMG, Marketkar S, Ng S, Manrai P, James Sung C, Bridge JA, Singh K. Int J Surg Pathol. 2025 May;33(3):689-699. doi: 10.1177/10668969241271420. Epub 2024 Oct 29. PMID: 39471995.

Multiomic Characterization of RCC1 and RCC2 Expression and Their Association With Molecular Alterations, Immune Phenotypes, and Cancer Outcomes

Nagasaka M, Warnecke B, Ou SI, Bannoura SF, Kim C, Elliott A, Halmos B, Hoon D, Darabi S, Sukari A, Radovich M, Lou E, Sledge G, El-Deiry W, Al-Hallak MN, Pasche BC, Azmi AS.  JCO Oncol Adv. 2025 May 1;2(1):00022. doi: 10.1200/OA-24-00033. PMID: 40330141; PMCID: PMC12052079.

Embedding Radical Prostatectomy Specimens: Selective with Regular Cassettes or Complete with Large Cassettes

Montironi R, Cimadamore A, Lopez-Beltran A, Rogers ET, Cheng L.  Virchows Arch. 2025 May;486(5):1105-1108. doi: 10.1007/s00428-025-04052-2. Epub 2025 Feb 17. PMID: 39960510.

Current Androgen Receptor Antagonists Under Investigation for Resistant Prostate Cancer: Progress and Challenges

Danielli L, Tassinari E, Marchetti A, Rosellini M, Mollica V, Cheng L, Massari F.  Expert Rev Anticancer Ther. 2025 May;25(5):457-470. doi: 10.1080/14737140.2025.2481141. Epub 2025 Mar 20. PMID: 40089934.

LINE-1 ORF1p Mimics Viral Innate Immune Evasion Mechanisms in Pancreatic Ductal Adenocarcinoma

You E, Patel BK, Rojas AS, Sun S, Danaher P, Ho NI, Phillips IE, Raabe MJ, Song Y, Xu KH, Kocher JR, Richieri PM, Shin P, Taylor MS, Nieman LT, Greenbaum BD, Ting DT. LINE-1 ORF1p Mimics Viral Innate Immune Evasion Mechanisms in Pancreatic Ductal Adenocarcinoma. Cancer Discov. 2025 May 2;15(5):1063-1082. doi: 10.1158/2159-8290.CD-24-1317. PMID: 39919290; PMCID: PMC12046326.
 


 

Molecular Characterization and Clinical Outcomes of Pancreatic Neuroendocrine Neoplasms Harboring PAK4-NAMPT Alterations

Azar I, Khan HY, Bannoura SF, Gandhi N, Uddin MH, Nagasaka M, Gong J, Nazha B, Choucair K, Vojjala N, Khushman MM, Soares HP, El-Deiry WS, Philip PA, El-Rayes B, Chen H, Lou E, Muqbil I, Farrell AP, Swensen J, Oberley MJ, Nabhan C, Goel S, Shields AF, Mohammad RM, Pasche BC, Azmi AS.  JCO Oncol Adv. 2025 May 2;2(1):e2400032. doi: 10.1200/OA-24-00032. PMID: 40330142; PMCID: PMC12052073.

Downregulation of Spermatogenesis-Associated Transcripts in the Spermatozoa of Idiopathic Infertile Men

Qi X, Ji H, Bianchi E, Hall SJ, Avellino G, Berg W, Bearelly P, Sigman M, Wu Z, Spade DJ.  Andrology. 2025 May 10:10.1111/andr.70060. doi: 10.1111/andr.70060. Epub ahead of print. PMID: 40346865; PMCID: PMC12354147.

Leukocyte Depletion in Dried Blood Spot Cards Enables Enrichment of Parasite DNA for Improved Sequencing

Tierney AJ, Prajapati SK, Leonetti A, Fola AA, Kwapong SS, Baillargeon KR, Roberds A, Stewart VA, Amoah LE, Bailey JA, Williamson KC, Mace CR.  Anal Chem. 2025 May 13;97(18):9691-9700. doi: 10.1021/acs.analchem.4c06190. Epub 2025 May 2. PMID: 40315381; PMCID: PMC12724477.

Nuclear SUMOylation and Proteotoxic Stress Responses to Metals with Different Ligand Preferences

Ursu GM, Krawic C, Zhitkovich A.  Chem Res Toxicol. 2025 May 19;38(5):942-953. doi: 10.1021/acs.chemrestox.5c00040. Epub 2025 Apr 17. PMID: 40243484; PMCID: PMC12308312.

Itaconate Modulates Immune Responses via Inhibition of Peroxiredoxin 5

Paulenda T, Echalar B, Potuckova L, Vachova V, Kleverov DA, Mehringer J, Potekhina E, Jacoby A, Sen D, Nelson C, Stegeman R, Sukhov V, Kemper D, Lichti CF, Day NJ, Zhang T, Husarcikova K, Bambouskova M, Fremont DH, Qian WJ, Djuranovic S, Pavlovic-Djuranovic S, Belousov VV, Krezel AM, Artyomov MN. Nat Metab. 2025 Jun;7(6):1183-1203. doi: 10.1038/s42255-025-01275-0. Epub 2025 Apr 18. PMID: 40251412.

Overexpression of the WWE Domain of RNF146 Modulates Poly-(SDP)-Ribose Dynamics at Sites of DNA Damage

Al-Rahahleh RQ, Roos WP, Saville KM, Andrews JF, Wu Z, Koczor CA, Prakash A, Sobol RW.  DNA Repair (Amst). 2025 Jun;150:103845. doi: 10.1016/j.dnarep.2025.103845. Epub 2025 May 21. PMID: 40403420; PMCID: PMC12320510.

Succinate Dehydrogenase Deficient Renal Cell Carcinoma Frequently Expresses GATA3 and L1CAM

Sangoi AR, Williamson SR, Oktay M, Gill AJ, Trpkov K, Siadat F, MacLean F, Galea LA, Baydar DE, Cakir C, Karabulut YY, Baycelebi D, Coban G, Sarsik B, Bayrak BY, Kuthi L, Posfai B, Mobeen A, Mohanty SK, Zhang X, Alghamdi MA, Cheng L, Hirsch MS, Akgul M.  Virchows Arch. 2025 Jun;486(6):1247-1256. doi: 10.1007/s00428-025-04078-6. Epub 2025 Mar 18. Erratum in: Virchows Arch. 2025 Sep;487(3):723-724. doi: 10.1007/s00428-025-04194-3. PMID: 40100385.

Juxtaglomerular Cell Tumour with Unusual Clear Cells: A Diagnostic Challenge and Differential Diagnosis

Poh EJ, Heng KH, Poh BK, Cheng L, Shi R, Tan PH.  Pathology. 2025 Jun;57(4):510-514. doi: 10.1016/j.pathol.2024.10.013. Epub 2025 Jan 21. PMID: 39988491.

Identifying Immunomodulatory Subpopulations of Adipose Stromal Vascular Fraction and Stem/Stromal Cells Through Single-Cell Transcriptomics and Bulk Proteomics

Parsons AM, Ahsan N, Darling EM. Stem Cell Rev Rep. 2025 Jun;21(5):1484-1500. doi: 10.1007/s12015-025-10889-6. Epub 2025 May 14. PMID: 40366552; PMCID: PMC12316552.

Dose-Response Assessment of Dipentyl Phthalate Effects on Testosterone Production and Morphogenesis of Late-Gestation Fetal Rat Testis

Gupta MV, Conley JM, Lambright C, Chin LF, Hall SJ, Gray LE, Spade DJ.  Environ Int. 2025 Jun;200:109551. doi: 10.1016/j.envint.2025.109551. Epub 2025 May 23. PMID: 40435860; PMCID: PMC12163936.

DNA Polymerase Beta Expression in Head & Neck Cancer Modulates the Poly(ADP-Ribose)-Mediated Replication Checkpoint

Khan MM, Roos WP, Pearson CR, Leonard SM, Angajala A, Gibbs DY, Liu JC, Ragin C, Sobol RW.  DNA Repair (Amst). 2025 Jun;150:103853. doi: 10.1016/j.dnarep.2025.103853. Epub 2025 Jun 2. PMID: 40472742; PMCID: PMC12281277.

Emergency Use Authorization for COVID-19 Polymerase Chain Reaction Kits: A Confusing Continuation

Waisberg M.  Arch Pathol Lab Med. 2025 Jun 1;149(6):496. doi: 10.5858/arpa.2024-0506-LE. PMID: 40419274.
 


 

p16, COX-2, and Ki67 Protein Expression in DCIS and Risk of Ipsilateral Invasive Breast Cancer

Rohan TE, Zhang C, Wang Y, Couch FJ, Greenlee RT, Honda S, Stark A, White LL, Chitale DA, Xue X, Ginsberg M, Loudig O.  Cancer Epidemiol Biomarkers Prev. 2025 Jun 3;34(6):1036-1039. doi: 10.1158/1055-9965.EPI-25-0143. PMID: 40227115; PMCID: PMC12133401.

Acquired Resistance to Molecularly Targeted Therapies for Cancer

Stubbs NM, Roady TJ, Schwermann MP, Eteshola EO, MacDonald WJ, Purcell C, Ryspayeva D, Verovkina N, Tajiknia V, Ghandali M, Voong V, Lannigan AJ, Raufi AG, Lawler S, Holder SL, Carneiro BA, Cheng L, Safran HP, Graff SL, Dizon DS, Mani SA, Seyhan AA, Sobol RW, Wong ET, Chen CC, Gokaslan Z, Taylor MS, Rivers BM, El-Deiry WS.  Cancer Drug Resist. 2025 Jun 5;8:27. doi: 10.20517/cdr.2024.189. PMID: 40510029; PMCID: PMC12159602.

Highly Multiplexed Molecular Inversion Probe Panel in Plasmodium Falciparum Targeting Common SNPs Approximates Whole-genome Sequencing Assessments for Selection and Relatedness

Niaré K, Crudale R, Fola AA, Wernsman Young N, Asua V, Conrad MD, Gashema P, Ghansah A, Hangi S, Ishengoma DS, Mazarati JB, Zeleke AJ, Rosenthal PJ, Djimdé AA, Juliano JJ, Bailey JA.  Front Genet. 2025 Jun 12;16:1526049. doi: 10.3389/fgene.2025.1526049. PMID: 40574802; PMCID: PMC12198981.

Case Report WIN-MTB-2023001 WIN International Molecular Tumor Board A 62-year-old male with metastatic colorectal cancer with 5 prior lines of treatment

Hernando-Calvo A, Kurzrock R, Gonzalez NS, Magidi S, Bresson C, Wunder F, Pretelli G, Casado AM, El-Deiry WS.  Oncotarget. 2025 Jun 17;16:456-466. doi: 10.18632/oncotarget.28744. PMID: 40526090; PMCID: PMC12175699.

TRIP12’s Role in the Governance of DNA Polymerase β Involvement in DNA Damage Response and Repair

Inanc B, Fang Q, Roos WP, Andrews JF, Zeng X, Clark J, Li J, Dey NB, Ibrahim M, Sykora P, Yu Z, Pearson CR, Braganza A, Verheij M, Jonkers J, Yates NA, Vens C, Sobol RW.  Nucleic Acids Res. 2025 Jun 20;53(12):gkaf574. doi: 10.1093/nar/gkaf574. PMID: 40613707; PMCID: PMC12231584.

Protocol for the Development, Assembly, and Testing of a Synthetic Skin Microbial Community

Thiruppathy D, Lekbua A, Coker J, Weng Y, Askarian F, Kousha A, Marotz C, Hauw A, Tjuanta M, Nizet V, Zengler K.  STAR Protoc. 2025 Jun 20;6(2):103714. doi: 10.1016/j.xpro.2025.103714. Epub 2025 Mar 25. PMID: 40138316; PMCID: PMC11985024.

Should Pathologists and Clinicians Continue to Consider Grade Group 1 (Gleason Score ≤6) Prostate Cancer as a True Carcinoma? Let’s Hear from Patient Advocates

Montironi R, Cimadamore A, Lopez-Beltran A, Rogers ET, Cheng L.  Arch Ital Urol Androl. 2025 Jun 30;97(2):13925. doi: 10.4081/aiua.2025.13925. Epub 2025 Jun 10. PMID: 40495744.

Presentation of Extended-Spectrum Beta-Lactamase-Producing Escherichia Coli Sequence Type 58 Strain (ST58) with Solid Subcutaneous Mass and Hypermucoid Phenotype: A Case Report

Carabaño M, Jang E, Charla S, Nau G, Geffert S, Gamsiz Uzun ED, Hong T. Ann Clin Lab Sci. 2025 Jul;55(4):590-595. PMID: 40962459.

Validation of an AI-Enabled Exome/Transcriptome Liquid Biopsy Platform for Early Detection, MRD, Disease Monitoring, and Therapy Selection for Solid Tumors

Abraham J, Domenyuk V, Perdigones N, Klimov S, Antani S, Yoshino T, Heath EI, Lou E, Liu SV, Marshall JL, El-Deiry WS, Shields AF, Dietrich MF, Nakamura Y, Fujisawa T, Demetri GD, Barker A, Xiu J, Sacchetti DA, Stahl S, Hahn-Lowry R, Stark A, Swensen J, Poste G, Halbert DD, Oberley M, Radovich M, Sledge GW, Spetzler DB.  Sci Rep. 2025 Jul 1;15(1):21173. doi: 10.1038/s41598-025-08986-0. PMID: 40596693; PMCID: PMC12214926.

Clinical Application of Large Language Models in Generating Pathologic Images

Zhu L, Lai Y, Ta N, Mou W, Montironi R, Collins K, Iczkowski KA, Chen F, Lopez-Beltran A, Zhou R, He H, Pareek G, Hyams E, Golijanin D, Khaleel S, Golijanin B, Malshy K, Cimadamore A, Ni X, Yang T, Cheng L, Chen R.  JCO Clin Cancer Inform. 2025 Jul;9:e2400267. doi: 10.1200/CCI-24-00267. Epub 2025 Jul 2. PMID: 40601882.

Genitourinary Pathology Society and International Society of Urological Pathology White Paper on Defining Indolent Prostate Cancer: Call for a Multidisciplinary Approach

Shah RB, Paner GP, Cheng L, De Marzo AM, Magi-Galluzzi C, Varma M, Zhou M, Amin A, Amin MB, Aron M, Cunha IW, Epstein JI, Fine SW, Haider A, Iczkowski KA, Kench JG, Kunju LP, Mohanty SK, Montironi R, Netto GJ, Pan CC, Rao P, Srigley JR, Sauter G, Tan PH, Tsuzuki T, van der Kwast TH, van Leenders GJ, Kristiansen G. Eur Urol. 2025 Jul;88(1):8-10. doi: 10.1016/j.eururo.2025.02.029. Epub 2025 Mar 17. PMID: 40102113.

Merkel Cell Carcinoma: Current Treatment Landscape and Emerging Therapeutic Targets

Pan K, Vromans AM, Cheng L, Grant-Kels JM, Katz SC, Hadfield MJ.  Curr Oncol Rep. 2025 Jul;27(7):822-832. doi: 10.1007/s11912-025-01693-z. Epub 2025 Jun 3. PMID: 40459726.

Corrigendum to Targeting Apoptotic Pathways for Cancer Therapy

Tian X, Srinivasan PR, Tajiknia V, Sanchez Sevilla Uruchurtu AF, Seyhan AA, Carneiro BA, De La Cruz A, Pinho-Schwermann M, George A, Zhao S, Strandberg J, Di Cristofano F, Zhang S, Zhou L, Raufi AG, Navaraj A, Zhang Y, Verovkina N, Ghandali M, Ryspayeva D, El-Deiry WS.  J Clin Invest. 2025 Jul 15;135(14):e196275. doi: 10.1172/JCI196275. Erratum for: J Clin Invest. 2024 Jul 15;134(14):e179570. doi: 10.1172/JCI179570. PMID: 40662371; PMCID: PMC12259242.

Polyglycine-Mediated Aggregation of FAM98B Disrupts tRNA Processing in GGC Repeat Disorders

Yang J, Xu Y, Ziehr DR, Taylor MS, Valenstein ML, Frenkel EM, Bush JR, Rutter K, Stevanovski I, Shi CY, Kesavan M, Pinto RM, Deveson I, Bartel DP, Sabatini DM, Chivukula RR.  Science. 2025 Jul 17;389(6757):eado2403. doi: 10.1126/science.ado2403. Epub 2025 Jul 17. PMID: 40674500; PMCID: PMC12603922.

Rising Prevalence of Plasmodium Falciparum Artemisinin Partial Resistance Mutations in Ethiopia

Brhane BG, Fola AA, Nigussie H, Leonetti A, Kassa M, Hailgiorgis H, Wuletaw Y, Abera A, Mohammed H, Sime H, G/Tsadik A, Assefa G, Solomon H, Tasew G, Tollera G, Hailu M, Juliano JJ, Assefa A, Parr JB, Bailey JA.  Commun Med (Lond). 2025 Jul 18;5(1):297. doi: 10.1038/s43856-025-01008-0. PMID: 40681807; PMCID: PMC12274420.

Predicting Neoadjuvant Chemotherapy Response in Triple-Negative Breast Cancer Using Pre-Treatment Histopathologic Images

Khan H, Su Z, Zhang H, Wang Y, Ning B, Wei S, Guo H, Li Z, Niazi MKK.  Cancers (Basel). 2025 Jul 22;17(15):2423. doi: 10.3390/cancers17152423. PMID: 40805125; PMCID: PMC12346615.

Reappraisal of Neuroendocrine Tumor Classification of the Prostate Gland: Translating Molecular Insights into Clinical Practice

Lobo A, Cheng L. Endocrine Patholology. 2025 Jul 23;36(1):28. doi: 10.1007/s12022-025-09871-2. PMID: 40699451.

Vimentin Intermediate Filaments as Structural and Mechanical Coordinators of Mesenchymal Cells

Guo M, Wong IY, Moore AS, Medalia O, Lippincott-Schwartz J, Weitz DA, Goldman RD.  Nat Cell Biol. 2025 Aug;27(8):1210-1218. doi: 10.1038/s41556-025-01713-x. Epub 2025 Aug 5. PMID: 40764390.

Assessment of Ex Vivo Antimalarial Drug Efficacy in African Plasmodium Falciparum Parasite Isolates, 2016-2023: A Genotype-Phenotype Association Study

Rosado J, Fola AA, Cojean S, Sarrasin V, Coppée R, Bailly J, Zaffaroulah R, Bouzayene A, Cicéron L, Houzé L, Crudale R, Musset L, Thellier M, Pradines B, Clain J, Bailey JA, Houzé S; Investigation Study Group. EBioMedicine. 2025 Aug;118:105835. doi: 10.1016/j.ebiom.2025.105835. Epub 2025 Jul 9. PMID: 40639048; PMCID: PMC12274720.

Myeloid Sarcomas of the Genitourinary Tract: A Multi-Institutional Study of Sixteen Tumors with Review of Literature

Shafi S, Mohanty SK, Williamson SR, Sharma S, Akgul M, Sangoi AR, Arora S, Acosta AM, Panda SS, Mishra SK, Deshwal A, Jha S, Mallik V, Lobo A, Dixit M, Kaushal S, Quiroga-Garza G, Cheng L, Shana'ah A, Parwani AV, Jaiswal AG, Dhillon J, Biswas G, Satturwar S.  Pathol Res Pract. 2025 Aug;272:156106. doi: 10.1016/j.prp.2025.156106. Epub 2025 Jul 3. PMID: 40618426.

Current Practices in Prostate Pathology Reporting: Results from a Survey of Genitourinary and General Pathologists

Nourbakshs M, Du L, Acosta AM, Alaghehbandan R, Amin A, Amin MB, Aron M, Berney D, Brimo F, Chan E, Cheng L, Colecchia M, Dhillon J, Downes MR, Evans AJ, Harik LR, Hassan O, Haider A, Humphrey PA, Jha S, Kandukuri S, Kao CS, Kaushal S, Khani F, Kryvenko ON, Kweldam C, Lal P, Lobo A, Maclean F, Magi-Galluzzi C, Mehra R, Miyamoto H, Mohanty SK, Montironi R, Nesi G, Netto GJ, Nguyen JK, Nourieh M, Osunkoya AO, Paner GP, Sangoi AR, Shah RB, Srigley JR, Tretiakova M, Troncoso P, Trpkov K, Van Der Kwast TH, Zhang M, Zynger DL, Williamson SR, Giannico GA.  Histopathology. 2025 Aug;87(2):206-222. doi: 10.1111/his.15469. Epub 2025 May 13. PMID: 40364451; PMCID: PMC12232231.

A Rapid, Simple, and Economical Method for the Isolation of Ribosomes and Translational Machinery for Structural and Functional Studies

Erath J, Kemper D, Mugo E, Jacoby A, Valenzuela E, Jungers CF, Beatty WL, Hashem Y, Jovanovic M, Djuranovic S, Pavlovic Djuranovic S. Nat Commun. 2025 Aug 5;16(1):7185. doi: 10.1038/s41467-025-62314-8. PMID: 40764614; PMCID: PMC12325604.

Artificial Intelligence in Prostate Cancer

Li W, Hu R, Zhang Q, Yu Z, Deng L, Zhu X, Xia Y, Song Z, Cimadamore A, Chen F, Lopez-Beltran A, Montironi R, Cheng L, Chen R.  Chin Med J (Engl). 2025 Aug 5;138(15):1769-1782. doi: 10.1097/CM9.0000000000003689. Epub 2025 Jul 9. PMID: 40629505; PMCID: PMC12321470.
 


 

Mutations in MLL3 Promote Breast Cancer Progression via HIF1α-Dependent Intratumoral Recruitment and Differentiation of Regulatory T Cells

Boutet M, Nishitani K, Couturier N, Erler P, Zhang Z, Militello AM, Coutinho De Miranda M, Barbieux E, Guillen E, Leavenworth JW, Suzuki M, Sparano JA, Lu J, Fineberg SA, Wang Y, Mani SA, Montagna C, Guo W, Lauvau G.  Immunity. 2025 Aug 12;58(8):2035-2053.e9. doi: 10.1016/j.immuni.2025.07.008. Epub 2025 Jul 31. PMID: 40749665; PMCID: PMC12344594.

OncoAID: An Open Access Targeted Anti-Cancer Drugs Database

Landau O, Magidi S, Bresson C, Wunder F, Kurzrock R, El-Deiry WS, Thangathurai K, Rubin E.  Front Pharmacol. 2025 Aug 13;16:1588191. doi: 10.3389/fphar.2025.1588191. PMID: 40880638; PMCID: PMC12380929.

A Deep Learning Model to Predict Glioma Recurrence Using Integrated Genomic and Clinical Data

Patricoski-Chavez JA, Nagpal S, Singh R, Warner JL, Gamsiz Uzun ED.  Commun Med (Lond). 2025 Aug 19;5(1):359. doi: 10.1038/s43856-025-01083-3. PMID: 40830273; PMCID: PMC12365200.

Intradural Extramedullary Solitary Plasmacytoma Originating in the Cervical Spine in the Setting of Refractory Multiple Myeloma: Illustrative Case

Wang EJ, Kozel G, Chuck CC, Punsoni M, Sullivan PZ.  J Neurosurg Case Lessons. 2025 Aug 25;10(8):CASE24731. doi: 10.3171/CASE24731. PMID: 40854251; PMCID: PMC12377174.

Malignant Brenner Tumor with Extensive Clear Cell Features: A Valuable Diagnostic Lesson Learned from Molecular Tumor Profiling and AI-Based Tumor Differential Tool

Steinharter JA, Jansen C, Ghani H, Nasir A, Capelletti M, Stuckey A, Quddus MR, Tseng YA.  Gynecol Oncol Rep. 2025 Aug 29;61:101939. doi: 10.1016/j.gore.2025.101939. PMID: 40977830; PMCID: PMC12447912.

Histopathologic Evidence of Intimal Hyperplasia in Carotid Artery Webs Associated with Stroke

Khan F, Nobee A, Lewis S, Donahue JE, Yaghi S. Free Neuropathol. 2025 Aug 26;6:16. doi: 10.17879/freeneuropathology-2025-7139. PMID: 40873957; PMCID: PMC12379831.

Interobserver Agreement in Scoring HER2-Negative and HER2-Low Immunohistochemistry in Breast Cancer: Reasons for Discordance and Impact of a Single Training Session

Tseng YA, Tamayo S, Abada E, Marketkar S, Hanley LC, Hansen K, Quddus MR, Sung CJ, Singh K.  Am J Clin Pathol. 2025 Aug 26;164(2):244-256. doi: 10.1093/ajcp/aqaf043. PMID: 40408397.

XPO1 R749Q Mutations Co-occur with POLE Mutations in Cancer and Can Be Targeted to Overcome Chemoresistance

Totiger TM, Chiraphapphaiboon W, Baca Y, Chaudhry S, Notti RQ, Montoya S, Chojnacka M, Gaidosh G, Afaghani J, Affer M, Armstrong C, Kavanaugh PM, Karaca E, Zabroski J, Lewis M, Maye A, Jahn J, Soni RK, Bilbao D, Walker P, Elliott A, Lou E, El-Deiry WS, Rodriguez JA, Nguyen HD, Taylor J. XPO1 R749Q Mutations Co-occur with POLE Mutations in Cancer and Can Be Targeted to Overcome Chemoresistance. Cancer Res. 2025 Sep 2;85(17):3219-3233. doi: 10.1158/0008-5472.CAN-24-3112. PMID: 40531821; PMCID: PMC12354660.

Diagnostic and Management Challenges in a Partially Infarcted Borderline Phyllodes Tumor in an Adolescent Female: A Case Report and Review of Literature

Suschana E, Sta Ines FM, Manrai P, Koelliker S, Gass JS, Tseng YA.  World J Clin Pediatr. 2025 Sep 9;14(3):102741. doi: 10.5409/wjcp.v14.i3.102741. PMID: 40881099; PMCID: PMC12304955.

PDE7A Inhibition Suppresses Triple-Negative Breast Cancer by Attenuating De Novo Pyrimidine Biosynthesis

Malvi P, Bugide S, Dutta R, Reddi KK, Edwards YJK, Singh K, Gupta R, Wajapeyee N. Cell Rep Med. 2025 Sep 16;6(9):102356. doi: 10.1016/j.xcrm.2025.102356. PMID: 40961924; PMCID: PMC12490241.

Antithrombin-Binding Heparan Sulfate Is Ubiquitously Expressed in Epithelial Cells and Suppresses Pancreatic Tumorigenesis

Clausen TM, Weiss RJ, Tremblay JR, Kellman BP, Coker J, Dworkin LA, Rodriguez JP, Chang IM, Chen T, Padala V, Karlsson R, Song H, Peck KL, Ogawa S, Sandoval DR, Joshi HJ, Wang G, Ferguson LP, Bhalerao N, Moores A, Reya T, Sander M, Caffrey TC, Grem JL, Aicher A, Heeschen C, Le D, Lewis NE, Hollingsworth MA, Grandgenett PM, Bellis SL, Miller RL, Fuster MM, Dawson DW, Engle DD, Esko JD.  J Clin Invest. 2025 Sep 16;135(22):e184172. doi: 10.1172/JCI184172. PMID: 40924474; PMCID: PMC12618072.

Barriers to Achieving Graduated Responsibility: Preparing Pathology Residents for Independent Practice

Bryant BH, Puligandla B, Gosnell HL, Johnson K, Barak S, Berg MP, Chahar S, Childs JM, Karp JK, Lofgreen A, McCloskey CB, Knollmann-Ritschel BEC, White KL, Black-Schaffer WS.  Academic Pathology. 2025 Sep 22;12(4):100221. doi: 10.1016/j.acpath.2025.100221. PMID: 41049715; PMCID: PMC12493152.

Toward Setting Minimum and Optimal Data to Report for Malaria Molecular Surveillance with Targeted Sequencing: The "What" and "Why"

Juliano JJ, Meier-Scherling CPG, Wernsman Young N, Tollefson GA, Connelly SV, Parr JB, Conrad MD, Sadler JM, Hennelly CM, Assefa A, Okell L, Fola AA, Niaré K, Marglous J, Carey-Ewend K, Futila Kyong-Shin R, Gerdes Gyuricza I, Cuomo-Dannenburg G, Ruybal-Pesántez S, Watson OJ, Verity R, Bailey JA.  Am J Trop Med Hyg. 2025 Sep 25;113(6):1169-1177. doi: 10.4269/ajtmh.25-0147. PMID: 40997786; PMCID: PMC12676599.

Genomic Profiling of Urological Malignancies Using Tissue-Based Next Generation Sequencing

Alruwaii ZI, Gokturk Ozcan G, Hassan O, Cheng L, Al-Obaidy KI.  Urol Oncol. 2025 Oct;43(10):534-543. doi: 10.1016/j.urolonc.2025.04.011. Epub 2025 May 22. PMID: 40410007.

In Response to Dr. James R. Wright, Jr.'s Letter to the Editor

Ferreira EO, Kostadinov S, Stefanovici C, Duncan V.  Pediatr Dev Pathol. 2025 Sep-Oct;28(5):431. doi: 10.1177/10935266251357785. Epub 2025 Jul 30. PMID: 40739788.

Application of RNA Sequencing in Urologic Malignancies: Advances and Challenges

Al-Obaidy KI, Cheng L.  Urol Oncol. 2025 Oct;43(10):544-552. doi: 10.1016/j.urolonc.2025.03.007. Epub 2025 Mar 21. PMID: 40121105.

Molecular Subtypes of Balanopreputial and Urethral Male Genital Lichen Sclerosus: Distinct Transcriptomic and Clinicopathological Profiles

Xiu X, Yu Z, Kravvas G, Bunker CB, Cheng L, Mao G, Tang J, Zhang R, Hao T, Yang L, Wang Z, Zhu W, Yuan W, Yin Z, Song L.  Lab Invest. 2025 Oct;105(10):104206. doi: 10.1016/j.labinv.2025.104206. Epub 2025 Jun 19. PMID: 40543717.

Molecular Testing in Urinary Cytology Specimens: Current Status and Future Directions

Chen F, Simsir A, Cheng L.  Urol Oncol. 2025 Oct;43(10):565-578. doi: 10.1016/j.urolonc.2025.02.009. Epub 2025 Mar 7. PMID: 40055071.

Genetic Profiling of Upper Tract Urothelial Carcinoma: A Necessity for Precision Medicine

Amin A, Khalatbari F, Cheng L.  Expert Rev Mol Diagn. 2025 Oct;25(10):695-708. doi: 10.1080/14737159.2025.2549834. Epub 2025 Aug 20. PMID: 40820359.

A Rare Genital Concomitant Presentation of Extracavitary Primary Effusion Lymphoma and Squamous Cell Carcinoma

Rajab K, Tsenter Y, Olszewski AJ, Liu L, Jackson C, Cheng L, Treaba DO.  RI Med J. 2025 Oct 1;108(10):18-21. PMID: 41002202.

Scalable Long-Read Nanopore HPV16 Amplicon-Based Whole-Genome Sequencing

Titus MK, Giesbrecht D, Oduor CI, Muthoka K, Niaré K, Crudale R, Fola AA, Hui ST, Kim IE Jr, Tonui PK, Itsura PM, Tonui R, Moormann AM, Loehrer PJ, Brown DR, Orang'o OE, Cu-Uvin S, Ermel AC, Katzenellenbogen RA, Bailey JA.  Sci Rep. 2025 Oct 7;15(1):34892. doi: 10.1038/s41598-025-18664-w. PMID: 41057388; PMCID: PMC12504524.

Pathologist-Like Explainable AI for Interpretable Gleason Grading in Prostate Cancer

Mittmann G, Laiouar-Pedari S, Mehrtens HA, Haggenmüller S, Bucher TC, Chanda T, Gaisa NT, Wagner M, Klamminger GG, Rau TT, Neppl C, Compérat EM, Gocht A, Haemmerle M, Rupp NJ, Westhoff J, Krücken I, Seidl M, Schürch CM, Bauer M, Solass W, Tam YC, Weber F, Grobholz R, Augustyniak J, Kalinski T, Hörner C, Mertz KD, Döring C, Erbersdobler A, Deubler G, Bremmer F, Sommer U, Brodhun M, Griffin J, Lenon MSL, Trpkov K, Cheng L, Chen F, Levi A, Cai G, Nguyen TQ, Amin A, Cimadamore A, Shabaik A, Manucha V, Ahmad N, Messias N, Sanguedolce F, Taheri D, Baraban E, Jia L, Shah RB, Siadat F, Swarbrick N, Park K, Hassan O, Sakhaie S, Downes MR, Miyamoto H, Williamson SR, Holland-Letz T, Wies C, Schneider CV, Kather JN, Tolkach Y, Brinker TJ.  Nat Commun. 2025 Oct 8;16(1):8959. doi: 10.1038/s41467-025-64712-4. PMID: 41062516; PMCID: PMC12508442.

Re: Francesca Ambrosini, Nataniele Piol, Matteo Bauckneht, et al. Immunohistochemical Prostate-specific Membrane Antigen (PSMA) Expression Patterns of Primary Prostate Cancer Tissue as a Determining Factor for Prostate Cancer Staging with PSMA...

Cimadamore A, Lopez-Beltran A, Cheng L, Montironi R. Re: Francesca Ambrosini, Nataniele Piol, Matteo Bauckneht, et al.  Eur Urol Oncol. 2025 Oct;8(5):1428-1429. doi: 10.1016/j.euo.2025.05.018. Epub 2025 Jun 11. PMID: 40500602.

A Brain Cancer Microtissue Model for Studying Tumor Cell and Neural Cell Interactions

Calvao DJ, Vecchio F, Zein-Sabatto A, Ocitti M, Vidomlanski R, Schmidt A, Shub M, Kesari H, Viapiano M, Lawler SE, Hoffman-Kim D.  Sci Rep. 2025 Oct 15;15(1):36021. doi: 10.1038/s41598-025-19982-9. PMID: 41094028; PMCID: PMC12528446.

AAV Kills Dividing Cells by Depleting PARP1 and Other DNA Damage Response Proteins

Friese S, Zai J, Luzbetak G, Khanna N, Gesperger J, Liu CH, Roos WP, Al-Rahahleh R, Willardson M, Yang F, Fu D, Han Y, Lintag N, Saykham J, Le J, Al-Delaimy E, Soutipan N, Duong E, Rich J, Marchetto MC, Rosenfeld M, Sobol RW, Shtrahman M.  bioRxiv [Preprint]. 2025 Oct 15:2025.10.14.682484. doi: 10.1101/2025.10.14.682484. PMID: 41279006; PMCID: PMC12632961.

Emergence and Rising Prevalence of Artemisinin Partial Resistance Marker Kelch13 P441L in a Low Malaria Transmission Setting in Southern Zambia

Martin AC, Sadler JM, Simkin A, Musonda M, Katowa B, Matoba J, Schue J, Simulundu E, Bailey JA, Moss WJ, Juliano JJ, Fola AA.  J Infect Dis. 2025 Oct 15;232(4):918-922. doi: 10.1093/infdis/jiaf188. PMID: 40241390; PMCID: PMC12526945.

Perceived Gaps in Preparation for Pathology Residency and Opportunities for Improvement

Knollmann-Ritschel BEC, Karp JK, Barak S, Childs JM, Johnson K, Lofgreen A, Berg MP, Chahar S, Gosnell HL, McCloskey CB, Puligandla B, White KL, Bryant B.  Academic Pathology. 2025 Oct 26;12(4):100223. doi: 10.1016/j.acpath.2025.100223. PMID: 41216342; PMCID: PMC12596605.

Genomic Aberration Detection by Fluorescence in Situ Hybridization

Cheng L, Davidson DD, Zhang S.  Hum Pathol. 2025 Nov;165:105906. doi: 10.1016/j.humpath.2025.105906. Epub 2025 Aug 7. PMID: 40782985.

The Role of Liquid Biopsy in the Management of Patients with Genitourinary Malignancies

Maughan BL, Dyrskjøt L, Grivas P, Alcaraz A, Antonarakis ES, Bilen MA, Bivalacqua T, Cooperberg MR, Cheng L, Gupta S. Eur Urol. 2025 Nov;88(5):449-461. doi: 10.1016/j.eururo.2025.07.016. Epub 2025 Aug 18. PMID: 40829964.

The Dublin International Society of Urological Pathology (ISUP) Consensus Conference on Best Practice Recommendations on the Pathology of Urachal Neoplasms

Reis H, Al-Ahmadie H, Gaisa NT, Lopez-Beltran A, Maclean F, Tsuzuki T, Werneck da Cunha I, Amin MB, Aning J, Aron M, Athanazio D, Bambury RM, Cheng L, Gopalan A, Gulmann C, Guo CC, Harris C, Iyer G, Jimenez RE, Jinzaki M, Kikuchi E, Lal P, Miyai K, Netto GJ, Pan CC, Panebianco V, van Rhijn BW, Siefker-Radtke A, Smith SC, Szarvas T, Wobker SE, Kristiansen G, Paner GP. Am J Surg Pathol. 2025 Nov 1;49(11):e18-e26. doi: 10.1097/PAS.0000000000002416. Epub 2025 Jun 5. PMID: 40471793; PMCID: PMC12517712.

Oleandrin-Mediated Suppression of MELK Induces Apoptosis, Autophagy, and Ferroptosis in Human Non-Small Cell Lung Cancer Cells

Omer EA, Zhou M, Roos WP, Rashan LJ, Fiebig HH, Klauck SM, Shan L, Efferth T.  Phytomedicine. 2025 Nov;147:157173. doi: 10.1016/j.phymed.2025.157173. Epub 2025 Aug 15. Erratum in: Phytomedicine. 2026 Oct;160:158669. doi: 10.1016/j.phymed.2026.158669. PMID: 40916237.

Interobserver Reproducibility of a Hybrid Three-Tier Grading System of Papillary Nonmuscle Invasive Urothelial Carcinoma: An International Uropathology Study

Downes MR, Lajkosz K, Algaba F, Allory Y, Amin MB, Cheng L, Desai S, Eckstein M, Hartmann A, Lopez-Beltran A, Mannweiler S, van Montfoort ML, Oxley J, Paner GP, Samaratunga H, Shen S, Warrick J, Williamson SR, Wobker SE, van der Kwast TH.  Histopathology. 2025 Nov;87(5):649-659. doi: 10.1111/his.15438. Epub 2025 Mar 9. PMID: 40058790; PMCID: PMC12522021.

Urinary Tumor DNA-based Liquid Biopsy in Bladder Cancer Management: A Systematic Review

Lee J, Chen F, Lopez-Beltran A, Necchi A, Cimadamore A, Spiess PE, Li R, Roy-Chowdhuri S, Montironi R, Golijanin D, Luchini C, Cheng L.  Eur Urol Focus. 2025 Nov;11(6):978-990. doi: 10.1016/j.euf.2025.06.009. Epub 2025 Aug 5. PMID: 40753029.

Serous Borderline Tumors of the Testis and Paratestis: A Clinicopathologic Study of 19 Tumors Emphasizing Morphologic Spectrum and Clinical Outcome

Shahabi A, Konstantinov A, McKenney JK, Lane J, Kao CS, Williamson SR, Alaghehbandan R, Cheng L, Sangoi AR, Chan E, Cornejo KM, Przybycin CG.  Am J Surg Pathol. 2025 Nov 1;49(11):1172-1179. doi: 10.1097/PAS.0000000000002439. Epub 2025 Jun 13. PMID: 40511957.

Interobserver Reproducibility of Hilar Soft Tissue Invasion in Testicular Germ Cell Tumours Among Genitourinary Pathologists

Wu DJ, Akgul M, Williamson SR, Pacheco R, Acosta A, Al-Obaidy K, Amin M, Berney D, Brimo F, Cheng L, Colecchia M, Compérat E, Cornejo K, Dhillon J, Downes M, Epstein JI, Hirsch MS, Jimenez R, Kaushal S, Lobo A, Lopez-Beltran A, Mehra R, Mohanty SK, Paner G, Rao P, Reuter V, Shah RB, Shen S, Smith S, Tretiakova M, Trpkov K, Wobker SE, Tamboli P, Zynger D, Sangoi AR.  Histopathology. 2025 Nov;87(5):677-686. doi: 10.1111/his.15504. Epub 2025 Jul 4. PMID: 40611804.

Climate Concerns for Clinicians: Evaluating Harmful Algal Bloom Knowledge and Educational Opportunities for Health Care Provider Students

Lund A, McNair C, McGowen C, Lowman J, Sobol R, Parsons M, Pierce J.  Front Med (Lausanne). 2025 Nov 4;12:1597926. doi: 10.3389/fmed.2025.1597926. PMID: 41262440; PMCID: PMC12623342.

Seeing Is Believing-Plasmodium Falciparum Translation in Action

Erath J, Pavlovic Djuranovic S. Structure. 2025 Nov 6;33(11):1818-1819. doi: 10.1016/j.str.2025.10.008. PMID: 41202797.

End Points for the Next-Generation Bladder-Sparing Perioperative Trials for Patients With Muscle-Invasive Bladder Cancer

Necchi A, Galsky MD, Dizman N, Aggen DH, Agarwal N, Al-Ahmadie H, Apolo AB, Ballas L, Bangs R, Black PC, Brausi M, Brembilla G, Cheng L, Chiti A, Cimadamore A, Colecchia M, Daneshmand S, Di Stasi S, Efstathiou JA, Filicevas A, Geynisman DM, Grivas P, Gupta S, Iasonos A, James ND, Lerner SP, Loriot Y, Makaroff LE, Maluf F, Moschini M, Ostrovnaya I, Pal SK, Plimack ER, Prakash G, Psutka SP, Rosenberg JE, Sadeghi S, Schmidt B, Schwartz LH, Sonpavde GP, St Laurent MP, Ye D, Spiess PE, Kamat AM. J Clin Oncol. 2025 Nov 10;43(32):3536-3544. doi: 10.1200/JCO-25-01608. Epub 2025 Sep 11. PMID: 40934451; PMCID: PMC12431632.

Immune Cell Profiling of Peripheral Blood in Long-Term Testicular Germ Cell Tumor Survivors

Kilikova K, Mlcakova A, Sestakova Z, Kalavska K, Adamikova K, Obertova J, Palacka P, Rejlekova K, Sycova-Mila Z, De Angelis V, Orszaghova Z, Lesko P, Svetlovska D, Mladosievicova B, Cheng L, Mego M, Chovanec M.  Front Immunol. 2025 Nov 13;16:1697087. doi: 10.3389/fimmu.2025.1697087. PMID: 41322405; PMCID: PMC12657365.

Macro-Microscopic Evaluation of Pathology Specimens with Large Format Histology. For the Benefit of ‘ Our Service Users and Patients’

Cimadamore A, Cheng L, Lopez-Beltran A, Franzese C, Rogers ET, Montironi R.  J Clin Pathol. 2025 Nov 19;78(12):861-862. doi: 10.1136/jcp-2024-209543. PMID: 38876776.

A Novel Sono-Activatable Nanoreactor Induces Precision Intratumoral Juglone Generation and Caspase 3/GSDME-Mediated Pyroptosis for Treatment of Bladder Cancer

Zhang Y, Yang E, Zhang X, Shi Y, Fan G, Wang Y, Tian J, Wang H, Dong Z, Wang Y, Cheng L, Zhao Z, Zhang Y, Wang B, Wang Z.  J Nanobiotechnology. 2025 Nov 22;23(1):795. doi: 10.1186/s12951-025-03855-4. PMID: 41275281; PMCID: PMC12752224.

Feedforward miR-181d Degradation Modulates Population Variance of Methyl-Guanine Methyl Transferase and Temozolomide Resistance

Singh G, Singh S, Mohapatra I, Kim S, Sharma M, Akers J, Nguyen T, Wong E, Moreno MM, Kokkoli E, Vasudevan S, Lawler SE, El-Deiry WS, Gokaslan Z, Chen CC.  Cell Rep. 2025 Nov 25;44(11):116516. doi: 10.1016/j.celrep.2025.116516. Epub 2025 Nov 10. PMID: 41217933; PMCID: PMC12767607.

Molecular Characterization of Pericardial Mesothelioma With Constrictive and Recurrent Pericarditis: TAZ Amplification and Hippo Pathway

Tudino R, Smith S, Cheng L, French K, Azzoli C.  JACC Case Rep. 2025 Nov 26;30(38):105759. doi: 10.1016/j.jaccas.2025.105759. Epub 2025 Oct 19. PMID: 41109993; PMCID: PMC12714527.

Protein-Protein Interactions in Papillary and Nonpapillary Urothelial Carcinoma Architectures: Comparative Study

Chou C, Baykara Y, Hacking S, Amin A, Cheng L, Uzun A, Gamsiz Uzun ED.  JMIR Bioinform Biotechnol. 2025 Nov 27;6:e76736. doi: 10.2196/76736. PMID: 41342186; PMCID: PMC12661593.

Role of the Tgf -β 1 Signaling Pathway in Modulating in Vivo Adaptation of Vascular Grafts

Zhang L, Li R, Xi Y, Xiao M, Xia D, Li X, Shu C.  Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2025 Nov 28;50(11):2104-2114. Chinese. doi: 10.11817/j.issn.1672-7347.2025.250493. PMID: 41656844; PMCID: PMC12949942.

Temporal Trends in Artemisinin Partial Resistance and Other Antimalarial Drug Mutations in Plasmodium falciparum from Kagera Region, Northwestern Tanzania, 2021-2023

Simkin A, Mandai S, Fola AA, Young NW, Pereus D, Bakari C, Madebe RA, Seth MD, Mrengela RB, Kisambale AJ, Chacha GA, Mandara CI, Francis F, Mbwambo D, Garimo I, Chacky F, Aaron S, Lusasi A, Molteni F, Njau RJA, Kajange S, Nhiga SL, Mohamed A, Juliano JJ, Ishengoma DS, Bailey JA.  medRxiv [Preprint]. 2025 Nov 28:2025.11.26.25341086. doi: 10.1101/2025.11.26.25341086. Update in: Front Genet. 2026 Jun 03;17:1776108. doi: 10.3389/fgene.2026.1776108. PMID: 41358296; PMCID: PMC12676548.

Re-Appraisal of Mucocele-Like Lesion of the Breast with Atypia: Study of 34 Cases with Focus on Impact of Type and Extent of Atypia on Upgrade

Sta Ines FM, Eadara A, Quddus MR, Sung CJ, Singh K.  Histopathology. 2025 Dec;87(6):943-950. doi: 10.1111/his.15534. Epub 2025 Aug 18. PMID: 40823858.

International Society of Urological Pathology Consensus on Cancer Precursor Lesions. Working Group 1: The Prostate

Iczkowski KA, De Marzo AM, Agarwal N, Berman DM, Cimadamore A, Fine SW, Greenland N, Khani F, Loda M, Lotan TL, Varma M, Chinnaiyan A, Giannarini G, Huang J, Montironi R, Netto GJ, Osunkoya AO, Ratliff T, Kristiansen G, Cheng L, van Leenders GJLH.  Am J Surg Pathol. 2025 Dec 1;49(12):e33-e45. doi: 10.1097/PAS.0000000000002430. Epub 2025 Jun 23. PMID: 40545966; PMCID: PMC12754735.

Differential Effects of Mercury Compounds on Mutagenicity, Genotoxicity and Repair of Uv-Dna Damage

Cyran A, Ursu GM, Krawic C, Zhitkovich A.  Toxicology. 2025 Dec;518:154277. doi: 10.1016/j.tox.2025.154277. Epub 2025 Sep 8. PMID: 40930455; PMCID: PMC12477637.

High-Grade Early-Onset Prostate Cancer: Assessment of TMPRSS2::ERG -Negative Tumors Suggests Low Frequency of Germline Alterations and a Pathogenic Role for HOXB13

Maharjan D, Siegmund S, Michalova K, Odintsov I, Hornick JL, Nair V, Idrees MT, Collins K, Gordetsky JB, Osunkoya AO, Cheng L, Miyamoto H, Sangoi AR, Wu DJ, Ricci C, Mollica V, Raspollini MR, Contreras F, Bernal MPP, Fernandez IM, Rodriguez A, Lobo A, Mohanty SK, Sharma S, Goksel M, Acosta AM.  Am J Surg Pathol. 2025 Dec 1;49(12):1279-1287. doi: 10.1097/PAS.0000000000002459. Epub 2025 Aug 1. PMID: 40745946.

International Society of Urological Pathology Consensus Meeting 2024: Working Group 2 Preneoplastic and Precursor Lesions of the Urinary Bladder

Downes MR, Lopez-Beltran A, Contieri R, Hansel DE, Paner GP, Shen S, van Rhijn BWG, Al-Ahmadie H, Amin MB, Brunelli M, Comperat E, Cookson MS, Faltas BM, Guo CC, Hartmann A, Kamat AM, Mertens LS, Ross JS, van der Kwast TH, Warrick J, Kristiansen G, Cheng L, Raspollini MR.  Am J Surg Pathol. 2025 Dec 1;49(12):e46-e57. doi: 10.1097/PAS.0000000000002440. Epub 2025 Jul 1. PMID: 40590266.

Development and Preclinical Evaluation of a Novel FGFR3-Targeted Antibody-Drug Conjugate in Bladder Cancer

Fan G, Luo X, Li K, Zhang Z, Chen C, Shi Y, Cui S, Wang Y, Wang D, Zhang Z, Dong Z, Tian J, Cheng L, Wang J, Zhai Z, Liu Y, Wang Z.  Asian J Pharm Sci. 2025 Dec;20(6):101095. doi: 10.1016/j.ajps.2025.101095. Epub 2025 Oct 13. PMID: 41809890; PMCID: PMC12704294.
 


 

Genitourinary Pathology Society and International Society of Urological Pathology White Paper on Defining Indolent Prostate Cancer

Shah RB, Paner GP, Cheng L, De Marzo AM, Magi-Galluzzi C, Varma M, Zhou M, Amin A, Amin MB, Aron M, Cunha IW, Epstein JI, Fine SW, Haider A, Iczkowski KA, Kench JG, Kunju LP, Mohanty SK, Montironi R, Netto GJ, Pan CC, Rao P, Srigley JR, Sauter G, Tan PH, Tsuzuki T, van der Kwast TH, van Leenders GJ, Kristiansen G.  Am J Surg Pathol. 2025 Dec 1;49(12):e27-e32. doi: 10.1097/PAS.0000000000002425. Epub 2025 May 30. PMID: 40444986; PMCID: PMC12509221.

Interventional Pathologist and Intraoperative Surgical Margin Evaluation of Radical Prostatectomy Specimens Ex-Vivo Confocal Microscopy vs. Frozen Section Evaluation

Cimadamore A, Cheng L, Lopez-Beltran A, Montironi R.  Pathologica. 2025 Dec;117(6):618-619. doi: 10.32074/1591-951X-1791. PMID: 41954348; PMCID: PMC13094308.

Interobserver Reproducibility of Pelvicalyceal Invasion in Renal Cell Carcinoma Nephrectomies Among Genitourinary Pathologists

Sangoi AR, Akgul M, Mubeen A, Humble R, Wu DJ, Pacheco R, Acosta A, Amin M, Aron M, Brimo F, Chan E, Cheng L, Cheville J, Collins K, Cornejo K, Dhillon J, Downes MR, Epstein JI, Hirsch M, Kapur P, Lobo A, Mehra R, Mohanty S, Netto G, Osunkoya AO, Paner G, Rao P, Saleeb R, Shah RB, Shen S, Smith S, Tickoo S, Tretiakova M, Trpkov K, Wobker S, Tamboli P, Zynger D, Williamson SR.  Am J Surg Pathol. 2025 Dec 1;49(12):1307-1314. doi: 10.1097/PAS.0000000000002456. Epub 2025 Jul 25. PMID: 40734292.

BrUOG360: A Phase Ib/II Study of Copanlisib in Combination with Rucaparib in Patients with Metastatic Castration-Resistant Prostate Cancer (mCRPC)

De Souza AL, Hadfield MJ, Lu S, Golijanin DJ, Wood R, Margolis J, Anderson K, Olszewski AJ, Holder SL, El-Deiry WS, Aggarwal RR, Mega AE, Carneiro BA.  Cancer Res Commun. 2025 Dec 1;5(12):2142-2148. doi: 10.1158/2767-9764.CRC-25-0651. PMID: 41231232; PMCID: PMC12690636.

Invasive Acantholytic Extramammary Paget's Disease of the Vulva With Mammary Carcinoma-Like Differentiation and MMR Loss: Report of an Unusual Case and Its Clinical Mimics

Claus J, Pearce J, Bojko A, Manrai P, Quddus MR, Marketkar S. Gynecol Oncol Rep. 2025 Dec 15;63:102007. doi: 10.1016/j.gore.2025.102007. PMID: 41561668; PMCID: PMC12813102.

Repeats Mimic Pathogen-Associated Patterns Across a Vast Evolutionary Landscape

Šulc P, Di Gioacchino A, Solovyov A, Sun S, Martis S, Marhon SA, Lindholm HT, Chen R, Hosseini A, Jiang H, Ly BH, Taylor MS, Mehdipour P, Abdel-Wahab O, Rusk N, Vabret N, LaCava J, De Carvalho DD, Monasson R, Cocco S, Greenbaum BD.  Cell Genom. 2025 Dec 10;5(12):101011. doi: 10.1016/j.xgen.2025.101011. Epub 2025 Sep 24. PMID: 40997813; PMCID: PMC12802575.

High Prevalence and Emerging Positive Association of kelch13 R622I and HRP2-Based RDT Negativity in Plasmodium Falciparum in Northern Ethiopia

Zeleke AJ, Fola AA, Tollefson GA, Niaré K, Leonetti A, Taropawala O, Marglous J, Crudale R, Brhane BG, Assefa A, Kiyuka P, Parr JB, Hailu A, Tegegne MA, Bailey JA. PLoS Pathog. 2025 Dec 11;21(12):e1013771. doi: 10.1371/journal.ppat.1013771. PMID: 41379859; PMCID: PMC12697994.

Uveal Melanocytoma without GNAQ/GNA11 Mutations

Kazmer ST, Frauches R, Galang C, Bishay M, Minckler DS, Mruthyunjaya P, Lin JH.  Ocul Oncol Pathol. 2025 Dec;11(4):260-266. doi: 10.1159/000549105. Epub 2025 Oct 21. PMID: 41403972; PMCID: PMC12705124.

Approaches for Identification of 5’ UTR Mutations Impacting Translation and Protein Production from Neurodevelopmental Disorder Genes

Plassmeyer SP, Florian CP, Chase R, Kasper MJ, Mueller S, Liu Y, McFarland White K, Sierra-Cortez L, Fischer AD, Jungers CF, Djuranovic SP, Djuranovic S, Dougherty JD.  Cell Rep Methods. 2025 Dec 15;5(12):101247. doi: 10.1016/j.crmeth.2025.101247. Epub 2025 Dec 3. PMID: 41344325; PMCID: PMC12859497.

Low-Grade Non-Muscle-Invasive Bladder Cancer: Molecular Landscape, Treatment Strategies and Emerging Therapies

Wen L, Miyagi H, Spiess PE, Yu A, Mendelsohn CL, Tan WS, Psutka SP, Lerner SP, Cheng L, Dyrskjøt L, Meeks JJ, Shariat SF, Gontero P, Pradere B, Steinberg GD, Kamat AM, Li R. Nat Rev Urol. 2025 Dec;22(12):846-861. doi: 10.1038/s41585-025-01072-0. Epub 2025 Sep 10. PMID: 40931081.

Inhibition of ITGB6 Stimulates Potent Anti-Tumor Responses in Immunocompetent Mouse Models of Head and Neck Squamous Cell Carcinoma and Pancreatic Adenocarcinoma

MacDonald WJ, Srinivasan PR, Pinho-Schwermann M, Zhang S, Tajiknia V, Purcell C, Strandberg J, Lannigan AJ, El-Deiry WS.  Am J Cancer Res. 2025 Dec 25;15(12):5317-5333. doi: 10.62347/MEAD1055. PMID: 41523261; PMCID: PMC12789914.

Mapping the Prevalence of Molecular Markers of Plasmodium Falciparum Artemisinin Partial Resistance in Africa: A Spatial-Temporal Modelling Study

Young NW, Meier-Scherling CPG, Cuomo-Dannenburg G, Tollefson GA, Connelly SV, Marglous J, Gyuricza IG, Carey-Ewend K, Kyong-Shin R, Popkin-Hall ZR, Zeleke AJ, Ishengoma DS, Fola AA, Simkin A, Niaré K, Parr JB, Conrad M, Okell LC, Ruybal-Pesántez S, Watson OJ, Juliano JJ, Bailey JA, Verity R.  medRxiv [Preprint]. 2025 Dec 23:2025.12.22.25342873. doi: 10.64898/2025.12.22.25342873. Update in: Lancet Infect Dis. 2026 Jul 7:S1473-3099(26)00237-9. doi: 10.1016/S1473-3099(26)00237-9. PMID: 41480040; PMCID: PMC12755267.

Uracil-DNA Glycosylase Deficiency Is Associated with Repressed Tumor Cell-Intrinsic Inflammatory Signaling and Altered Sensitivity to Exogenous Interferons

Vendetti FP, Pandya P, Sclafani CR, Pathak S, Buj R, Jones RE, Ivanov D, Aird KM, Sobol RW, Bakkenist CJ.  NAR Cancer. 2025 Dec 31;7(4):zcaf054. doi: 10.1093/narcan/zcaf054. PMID: 41480637; PMCID: PMC12754777.

Replication-Associated Base Excision Repair/Single-Strand Break Repair Regulates PARG Inhibitor Response via the PRMT1/PRMT5/ATR Axis

Ibrahim M, Roos WP, Schwartz JC, Khan MM, Al-Rahahleh RQ, Beers LA, Pearson CR, Langham KT, Boyang L, Clark J, Hayat F, Fang Q, Koczor CA, Migaud ME, Sobol RW.  NAR Cancer. 2025 Dec 31;7(4):zcaf057. doi: 10.1093/narcan/zcaf057. PMID: 41480640; PMCID: PMC12754786.

Clinicopathological and Molecular Analysis of a Dermatofibrosarcoma Protuberans with Fibrosarcomatous Transformation in the Breast

Liu L, Dizon D, DiPetrillo TA, Hart J, Cheng L, Wang Y. NPJ Precis Oncol. 2025 Apr 15;9(1):107. doi: 10.1038/s41698-025-00905-w. PMID: 40229546; PMCID: PMC11997163.

Recent Advancements in Biomarkers and Molecular Diagnostics in Hormonal Receptor-Positive Breast Cancer

Wang Y, Liu L, Graff SL, Cheng L. Histopathology. 2025 Jul;87(1):3-17. doi: 10.1111/his.15395. Epub 2024 Dec 17. PMID: 39687977.